There's more gambling in PLO. Sometimes it feels that you lose more money faster. Any random 3 players with any random 4 cards will have some equity to play their hand on the same board. And you lose with aces so frequently, they never hold. You definitely need a bigger bankroll to play hands and see flops. And you need to be strong mentally because you get rivered occasionally because players will continue with their hands because of equities being so close. If it makes any sense to you.
I mostly play Hold'em because it's the game I started with and feel most comfortable in. But PLO is definitely more exciting sometimes-so much action and bigger pots! Still, Hold'em is my main game.