From my own experience, 100 or even 1,000 hands isn't really enough to judge a strategy. Variance in poker can make a bad strategy look good (or a solid one look terrible) over a small sample. I personally think you start getting real insight after at least 10,000 hands, and ideally 50,000+ to spot consistent patterns in winrate and leaks.
That said, I also believe quality of review matters as much as quantity. Even in a smaller sample, if you're analyzing your hands carefully — understanding why a play worked or failed — you can evolve quickly. I’ve changed some strategies after just 500 hands, but only because I saw repeating mistakes and backed it up with study.
So for me, the combo is: play thousands of hands, but also review deeply. That’s where real improvement lives.
This thread below may could help you explore this aspect:
Hello CC members, Everything in the title :D I wonder from which amount of hands played does ROI start to really make sense. Thanks for your answers.
www.cardschat.com
Good luck with your strategies!